Reviving a Drug for Tuberculosis ?

A compound called SMARt-420 renders ethionamide-resistant strains of Mycobacterium tuberculosis fully susceptible.

Published in: New England J. of Medicine,

June 8th, 2017

By: Eric J. Rubin

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420

 Published in: Science, March 17th, 2017, Vol. 355, Issue 6330, pp. 1206-1211

By: Nicolas Blondiaux et al.

A novel genome-editing platform for drug-resistant Acinetobacter baumannii reveals an AdeR-unrelated tigecycline resistance mechanism

Published in: Antimicrob Agents Chemother 2016, 60:7263–7271. doi:10.1128/AAC.01275-16.

By: Trebosc V et al.

Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approach

Published in:J. Med. Chem. 2014,57(11),pp 4876–4888

By: Villemagne B et al.

BioVersys Works to Bring Antibiotic Resistance to an End

Published in:   CHIMIA International Journal for Chemistry, Volume 68, Number 12, December 2014, pp. 888-890(3)

By: Tigges, Marcel; Gitzinger, Marc

Adjuvant strategies for potentiation of antibiotics to overcome antimicrobial resistance.

Published in: Curr Opin Pharmacol. 2012 Oct;12(5):551-5. doi: 10.1016/j.coph.2012.07.005. Epub 2012 Jul 25

By: Pieren M, Tigges M

Phenylethyl butyrate enhances the potency of second-line drugs against clinical isolates of Mycobacterium tuberculosis.

Published in: Antimicrob Agents Chemother. 2012 Feb;56(2):1142-5. doi: 10.1128/AAC.05649-11. Epub 2011 Nov 21

By: Grau T et al.

Discovery of novel N-phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis.

Published in: J. Med. Chem., 2012 vol. 55(14) pp. 6391-402

By: Flipo M et al.

Tuberculosis: the drug development pipeline at a glance.

Published in: Eur J Med Chem, 2012 vol. 51 pp. 1-16

By: Villemagne B et al.

Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands.

Published in: Nucleic Acids Res., 2012 vol. 40(7) pp. 3018-30

By: Carette X et al.