STRUCTURAL ACTIVATION OF THE TRANSCRIPTIONAL REPRESSOR ETHR FROM MYCOBACTERIUM TUBERCULOSIS BY SINGLE AMINO ACID CHANGE MIMICKING NATURAL AND SYNTHETIC LIGANDS.

Published in: Nucleic Acids Res., 2012 vol. 40(7) pp. 3018-30

By: Carette X et al.


ETHIONAMIDE BOOSTERS. 2. COMBINING BIOISOSTERIC REPLACEMENT AND STRUCTURE-BASED DRUG DESIGN TO SOLVE PHARMACOKINETIC ISSUES IN A SERIES OF POTENT 1,2,4-OXADIAZOLE ETHR INHIBITORS.

Published in: J. Med. Chem., 2012 vol. 55(1) pp. 68-83

By: Flipo M et al.


MALDI IMAGING TECHNIQUES DEDICATED TO DRUG-DISTRIBUTION STUDIES.

Published in: Bioanalysis, 2011 vol. 3(12) pp. 1399-406

By: Bonnel D et al.


ETHIONAMIDE BOOSTERS: SYNTHESIS, BIOLOGICAL ACTIVITY, AND STRUCTURE-ACTIVITY RELATIONSHIPS OF A SERIES OF 1,2,4-OXADIAZOLE ETHR INHIBITORS.

Published in: J. Med. Chem., 2011 vol. 54(8) pp. 2994-3010

By: Flipo M et al.


EXPLORING DRUG TARGET FLEXIBILITY USING IN SITU CLICK CHEMISTRY: APPLICATION TO A MYCOBACTERIAL TRANSCRIPTIONAL REGULATOR.

Published in: ACS Chem. Biol., 2010 vol. 5(11) pp. 1007-13

By: Willand N et al.


SYNTHETIC ETHR INHIBITORS BOOST ANTITUBERCULOUS ACTIVITY OF ETHIONAMIDE.

Published in: Nat. Med., 2009 vol. 15(5) pp. 537-44

By: Willand N et al.


A SYNTHETIC MAMMALIAN GENE CIRCUIT REVEALS ANTITUBERCULOSIS COMPOUNDS.

Published in: Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9994-8. doi: 10.1073/pnas.0800663105. Epub 2008 Jul 9

By: Weber W et al.


STRUCTURE OF ETHR IN A LIGAND BOUND CONFORMATION REVEALS THERAPEUTIC PERSPECTIVES AGAINST TUBERCULOSIS.

Published in: Mol Cell. 2004 Oct 22;16(2):301-7

By: Frénois F et al.

Video


ETHR, A REPRESSOR OF THE TETR/CAMR FAMILY IMPLICATED IN ETHIONAMIDE RESISTANCE IN MYCOBACTERIA, OCTAMERIZES COOPERATIVELY ON ITS OPERATOR.

Published in: Mol Microbiol. 2004 Jan;51(1):175-88

By: Engohang-Ndong J et al.